Obesity is a result of an imbalance between energy intake and expenditure.Excess fat accumulation strongly affects metabolic changes that increases the chances of glucose intolerance, insulin resistance, dyslipidemia, atherosclerosis, hypertension, coronary heart disease, congestive heart failure, stroke, cancers etc.
Overweight and obesity are the 5th leading risk factor for global mortality. At least 2.8 million adults die each year as result of being obese. Overall, more than one in ten of world’s adult population is obese. In 2010, nearly 43 million children (under the age of five) were overweight. Obesity is escalating at an alarming rate.
Since obesity has grown to epidemic proportions, its effective management is a very important clinical issue. Although great amounts of scientific effort has been put in to understand the mechanisms that lead to obesity, only a few are successful in the long term. Different pharmacological approaches include appetite and food suppressants, increasing energy expenditure and influencing metabolism.
One approach that has been gaining popularity is the alternative therapy using nutritional supplements for effective management of obesity. Many botanical drugs provide safe, natural, and cost-effective alternatives when compared to synthetic drugs. Botanical drugs can also be developed faster and cheaper then conventional single-entity pharmaceuticals.
The Global Market for weight Loss is expected to be worth US$586.3 Billion by 2014.